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La recaudación de fondos de la AGDQ tiene un "gran efecto" en la investigación sobre la prevención del cáncer, dice un médico

Dr. Brandon Gheller.


Sara Mahoney

El Dr. Brandon Gheller quedó asombrado al ver a los corredores de velocidad abrirse camino a través de los videojuegos durante su visita en enero a Awesome Games Done Quick (AGDQ) en Pittsburgh.

“It’s unbelievable how bad I am at video games,” he said. “Growing up I thought I was pretty good, but it’s pretty unbelievable to watch people at the top of their game literally be able to do things this quickly and build a community [around it].”

Pero la visita de Gheller a AGDQ fue para algo más que observar con asombro las carreras rápidas. Quería mostrar su apoyo a la evento que recaudó más de $2.5 millones para que investigadores como él puedan financiar sus proyectos de prevención y detección temprana del cáncer.

Gheller, investigador del Boston Children's Hospital, dijo que una cosa que hace que la recaudación de fondos de AGDQ sea tan única es que se centra en la prevención y la detección temprana del cáncer, en lugar del tratamiento.

“The funding makes an unbelievable amount of difference. It’s coming from a foundation that believes in preventing cancer, which keeps researchers who want to focus on preventing cancer versus treating cancer, in the game.”

Gheller explicó en detalle los esfuerzos de prevención del cáncer que apoya la AGDQ.

“We work on a disorder called clonal hematopoiesis. In the past 10 years, we’ve come to understand that 4% of all people have a change in their DNA and one of the stem cells that makes all the blood in their body. What happens is when you take on this change in DNA, that predisposes you to cancer. So this one stem cell starts to make more and more blood within your body, which can lead to things like leukemia, it can also lead to things like heart disease,” he explained. “So, what I’m personally doing is finding a way that we can stop these mutant or DNA change stem cells from growing in individuals and starting cancer.”

In an interview during AGDQ, Dr. Brandon Gheller explains how the money raised will help cancer prevention research.

In an interview during AGDQ, Dr. Brandon Gheller explains how the money raised will help cancer prevention research. (Courtesy: Santino Palazzolo)

También detalló su proceso de investigación.

“We use the zebrafish— a very small, tropical fish. We’re able to perfectly [replicate] what you see in a human in the fish. So now you can start to build interventions and test them on the fish,” he said. “And because this disorder isn’t cancer by nature, you don’t want to treat it with a drug, you’re able to treat healthy people who just might have this change in DNA.” “It’s an unbelievably exciting area to be in. We’ve only really known about this disorder because of advances in technology for 12 years. I already have research indicating that there’s a metabolic pathway that can be shut down to stop this disorder. It’s currently working in the zebrafish, it’s also working in human cells. [This progress] is really remarkable in this field,” he said.

Gheller dice que el impacto del dinero recaudado por AGDQ en 2024 se sentirá en las próximas décadas.

“Getting that funding and putting it toward preventing cancer – it’s something that we all believe can really have a huge effect on the field for the next 40, 50 years,” he said.

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COMPRUÉBALO | Inicie una recaudación de fondos en streaming con Prevent Cancer Foundation

La Fundación Prevent Cancer otorga subvenciones y becas de investigación a científicos prometedores que inician su carrera con hipótesis novedosas para la prevención y la detección temprana. Para obtener más información sobre el trabajo del Dr. Gheller y otros investigadores financiados por la Fundación, visite preventcancer.org/research.