La collecte de fonds de l'AGDQ a un « effet énorme » sur la recherche sur la prévention du cancer, selon un médecin

Dr. Brandon Gheller.


Sarah Mahoney

Le Dr Brandon Gheller était impressionné en regardant les speedrunners se frayer un chemin à travers les jeux vidéo lors de sa visite en janvier à Awesome Games Done Quick (AGDQ) à Pittsburgh.

“It’s unbelievable how bad I am at video games,” he said. “Growing up I thought I was pretty good, but it’s pretty unbelievable to watch people at the top of their game literally be able to do things this quickly and build a community [around it].”

Mais la visite de Gheller à l'AGDQ ne se limitait pas à regarder les speedruns avec admiration. Il voulait montrer son soutien au événement qui a permis de récolter plus de $2,5 millions afin que des chercheurs comme lui puissent financer leurs projets de prévention et de détection précoce du cancer.

Gheller, chercheur au Boston Children's Hospital, a déclaré que ce qui rend la collecte de fonds de l'AGDQ si unique est qu'elle se concentre sur la prévention et la détection précoce du cancer, par opposition au traitement.

“The funding makes an unbelievable amount of difference. It’s coming from a foundation that believes in preventing cancer, which keeps researchers who want to focus on preventing cancer versus treating cancer, in the game.”

Gheller a expliqué en détail les efforts de prévention du cancer soutenus par l'AGDQ.

“We work on a disorder called clonal hematopoiesis. In the past 10 years, we’ve come to understand that 4% of all people have a change in their DNA and one of the stem cells that makes all the blood in their body. What happens is when you take on this change in DNA, that predisposes you to cancer. So this one stem cell starts to make more and more blood within your body, which can lead to things like leukemia, it can also lead to things like heart disease,” he explained. “So, what I’m personally doing is finding a way that we can stop these mutant or DNA change stem cells from growing in individuals and starting cancer.”

In an interview during AGDQ, Dr. Brandon Gheller explains how the money raised will help cancer prevention research.

In an interview during AGDQ, Dr. Brandon Gheller explains how the money raised will help cancer prevention research. (Courtesy: Santino Palazzolo)

Il a également détaillé son processus de recherche.

“We use the zebrafish— a very small, tropical fish. We’re able to perfectly [replicate] what you see in a human in the fish. So now you can start to build interventions and test them on the fish,” he said. “And because this disorder isn’t cancer by nature, you don’t want to treat it with a drug, you’re able to treat healthy people who just might have this change in DNA.” “It’s an unbelievably exciting area to be in. We’ve only really known about this disorder because of advances in technology for 12 years. I already have research indicating that there’s a metabolic pathway that can be shut down to stop this disorder. It’s currently working in the zebrafish, it’s also working in human cells. [This progress] is really remarkable in this field,” he said.

Gheller affirme que l’impact de l’argent collecté par l’AGDQ en 2024 se fera sentir pendant des décennies à venir.

“Getting that funding and putting it toward preventing cancer – it’s something that we all believe can really have a huge effect on the field for the next 40, 50 years,” he said.

LIRE LA SUITE | 5 ans après le diagnostic du cancer des testicules, le Keizaron de l'AGDQ est sans cancer

VÉRIFIEZ-LE | Lancez une collecte de fonds en streaming avec la Prevent Cancer Foundation

La Fondation Prevent Cancer accorde des subventions de recherche et des bourses à des scientifiques prometteurs en début de carrière qui proposent de nouvelles hypothèses en matière de prévention et de détection précoce. Pour en savoir plus sur les travaux du Dr Gheller et d'autres chercheurs financés par la Fondation, visitez http://preventcancer.org/research.