Research progress report: Folic acid and breast cancer risk

July 31, 2015

Ligi Paul in lab1

We’re donning our brightest shades of pink this month to raise awareness of breast cancer.

This year, an estimated 232,670 women and 2,360 men will be diagnosed with invasive breast cancer. Nearly 40,430 people will die of the disease.

In support of Breast Cancer Awareness Month, we asked Foundation research awardee Ligi Paul, PhD, of Tufts University to give us an update on her study of folic acid and breast cancer risk.

Dr. Paul’s project is one of 95 projects on breast cancer that the Prevent Cancer Foundation has funded. Her project investigates a variation in the gene that is necessary to convert folic acid in vitamin supplements into a form easily absorbed by the body. This mutation is associated with a 52% increase risk of breast cancer in women who use multivitamins. Dr. Paul will study how genetic variations affect the body’s use of folic acid in ways that may increase cancer risk.

Ligi Paul_photo2

What led to your interest in breast cancer prevention research?
There is a strong link between gene-nutrient interaction and cancer risk. My interest in folic acid, a nutrient in the Vitamin B complex, and its reactions fueled my interest in how changes in its metabolism may increase cancer risk.

How will your current research project advance the field of cancer prevention?
We already know from previous research that a common variation in a gene responsible for converting folic acid to a form that can be absorbed into the body appears to increase cancer risk in people who take multivitamins. Using funding from the Prevent Cancer Foundation, I am investigating how this genetic variation increases the cancer risk and how it might be alleviated. I hope the results of this study can help to formulate measures to reduce this risk for cancer.

How is your research progressing?
The project is progressing well. We have recruited volunteers to participate in the study, and we are now in the phase of determining how the variation in the gene for folic acid conversion affects cellular metabolism and contributes to increased cancer risk.

An investment in cancer prevention is an investment in the future. The Foundation has been funding cancer prevention research since 1986. Our peer-reviewed grants and fellowships have been awarded to 407 early-career scientists from leading academic medical centers nationwide. Learn more about our research grant and fellowship program.

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